{"id":23,"date":"2024-06-06T18:05:42","date_gmt":"2024-06-06T18:05:42","guid":{"rendered":"https:\/\/stgchonquer.wpenginepowered.com\/?page_id=23"},"modified":"2026-04-23T08:34:57","modified_gmt":"2026-04-23T08:34:57","slug":"faq","status":"publish","type":"page","link":"https:\/\/chonquer.com\/en-ca\/faq\/","title":{"rendered":"FAQ"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"23\" class=\"elementor elementor-23\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59c3f0b header-background e-flex e-con-boxed e-con e-parent\" data-id=\"59c3f0b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b53e5c4 e-flex e-con-boxed e-con e-child\" data-id=\"b53e5c4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41396a4 elementor-widget elementor-widget-heading\" data-id=\"41396a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-41396a4{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a77e0d8 elementor-widget elementor-widget-heading\" data-id=\"a77e0d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">FAQsAus<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c407b2c elementor-widget elementor-widget-heading\" data-id=\"c407b2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Here, you will find answers to other questions you may have about this study.  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8f12c40 e-flex e-con-boxed e-con e-child\" data-id=\"8f12c40\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8130754 e-flex e-con-boxed e-con e-parent\" data-id=\"8130754\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7dc6bea elementor-widget elementor-widget-toggle\" data-id=\"7dc6bea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-7dc6bea{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe33576 elementor-widget elementor-widget-toggle\" data-id=\"fe33576\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2661\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2661\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are clinical trials?  <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2661\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2661\"><p>Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials\u202flook at new ways to prevent, detect, or treat disease. Clinical trials can study: new drugs or new combinations of drugs. They are tightly regulated with specific criteria for gathering data and most importantly, protect the patient participating in the clinical trial.<\/p><p>Your care and treatment are carefully monitored and controlled. The medical team conducting the trial will inform you about every possible outcome and they\u2019ll explain everything that is occurring. Finally, you are free to stop the trial at any time. You can request information about clinical trials, and presuming you meet the trial criteria, you can participate in a clinical trial at any point in your cancer journey.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2662\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2662\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How does the research process work? <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2662\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2662\"><p>A clinical trial is led by a principal investigator (PI). Members of the research team regularly monitor the participants\u2019 health through testing to determine the study\u2019s safety and effectiveness. Participating in a clinical trial may take more time than standard treatment, and you may have more tests and treatments than you would if you were not participating in a clinical trial. The study team also may ask you to keep a log of symptoms or other health measures, fill out forms about how you feel, or complete other tasks. You may also need to travel to take part in a study.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2663\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2663\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is IDH1 mutation and what does it mean to me?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2663\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2663\"><p>The IDH1 gene mutation refers to a specific alteration in the isocitrate dehydrogenase 1 (IDH1) that affects how cells produce energy and function. This mutation can lead to the buildup of a substance called D-2-hydroxyglutarate (2-HG), which interferes with normal cell function, including DNA repair and gene regulation. This disruption can contribute to cancer development and progression. Approximately 50% of conventional chondrosarcomas have an IDH1 mutation.<\/p><p>For people with chondrosarcoma, having an IDH1 mutation may make them eligible for the CHONQUER study. This clinical trial is assessing an investigational treatment targeting the IDH1 mutation, offering a potential option for managing this condition.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2664\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2664\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is the difference between a clinical study and my regular medical care?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2664\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2664\"><p>The purpose of regular medical care is to improve or otherwise manage your health. A clinical study does not replace your regular medical care. Its purpose is to gather information to advance science and discover new treatments.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2665\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2665\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Who is eligible for a clinical study? <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2665\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2665\"><p>Each clinical trial defines who is eligible to take part in the study. The protocol outlines the factors which include or exclude a potential participant. The study must include only people who match the required characteristics of participants for that study.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2666\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-2666\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is a Placebo?\u00a0<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2666\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-2666\"><p>Clinical trials compare a new medication, new product, or new procedure with another that already exists. In these types of studies, you may be assigned to receive a <span style=\"font-weight: 500;\">placebo<\/span>. A placebo is a \u201csugar pill\u201d that resembles medication, or a product being tested but has no treatment value. Clinical trial participants may receive a placebo to compare results on the risks and benefits of a medication and learn from their differences.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2667\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-2667\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is Randomization?\u00a0<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2667\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-2667\"><p>Randomization in clinical trials means that each participant has an equal chance of being in any of the groups of the trial (for example, a group receiving the study medicine or a group receiving the placebo). It is an important method to reduce the risk of bias in the outcomes of the trial.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2668\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-2668\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is a Blinded study (single-blind\/double-blind)?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2668\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-2668\"><p>Blinded studies are designed to prevent members of the research team and clinical trial participants from influencing the results by not knowing if the patient is receiving placebo or treatment.<\/p><p>In\u202fa <span style=\"font-weight: 500;\">single-blind <\/span>study, you are not told what is being given, but the research team knows.<\/p><p>In a <span style=\"font-weight: 500;\">double-blind<\/span> study, neither you nor the research team are told what you are given. Members of the research team are not told which participants are receiving which treatment to reduce bias. If it becomes medically necessary, however, it is always possible to find out which treatment you are receiving.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2669\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-2669\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Unblinding and Cross-over\u00a0<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2669\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-2669\"><p>In a blind study, all participants are monitored to determine if the medication or product being studied is safe and effective. If participants in this particular clinical trial who are being monitored show that the chondrosarcoma is getting worse on the radiographic images, the researchers will unblind the study to determine if you received the medication or a placebo. If you received a placebo, you would have the option to take the medication being studied and continue with the trial. If you were on the medication itself, the investigator will determine if you could still benefit by continuing the study treatment or not.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-26610\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-26610\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What is informed consent? <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-26610\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-26610\"><p>Informed consent is the process of providing you with all the key information about a research study before you decide whether to accept the offer to participate.<\/p><p><span style=\"font-weight: 500;\">It is very important that you fully understand the terms, conditions, risks and benefits.<\/span><\/p><p>Taking part in a clinical trial is voluntary and you can leave the study at any time. To participate, it will be necessary for you to sign an informed consent document. To help you decide whether to take part in the clinical trial, the staff of the research team are responsible for explaining all the details of the study and making sure you understand the research process as well as the terms and conditions of the study.<\/p><p>The research team provides an informed consent document that includes details about the study, such as its purpose, how long it\u2019s expected to last, tests or procedures that will be done as part of the research, and who to contact for further information. The informed consent document also explains the risks and potential benefits. Once you understand all the conditions included in the document, you can then decide whether to participate and sign the document.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-26611\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-26611\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How long do I need to take part in this clinical study?\u00a0<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-26611\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-26611\"><p>The length of a clinical study can vary, but the CHONQUER study lasts until your disease really worsens or in case too many side effects are encountered. Prior to being included in this study, there is a period where your doctor will assess if all conditions needed to be included are met. If you join, you will take the study medication (or placebo) daily and attend regular check-ups to monitor your health. After treatment, follow-up visits will check your progress. Taking part in a clinical study is entirely voluntary (your choice), and you can leave at any time without explanation or any negative impact on your regular healthcare. Additionally, the study team may stop your participation if needed for health or safety reasons.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-26612\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-26612\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Glossary for the Video<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-26612\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-26612\"><p><span style=\"font-weight: bold;\">\u201cConventional&#8221;: <\/span>\u202f&#8221;Conventional&#8221; in general means something that is traditional, standard, or commonly used and accepted. In the video it is mentioned in the context of \u201cconventional chondrosarcoma&#8221;.\u00a0 Conventional chondrosarcoma is a type of cancer that starts in the cartilage, which is the tough, flexible tissue that helps cushion joints and supports various structures in the body. It is a cancer that forms in the cartilage cells. This type of cancer typically grows slowly and can cause pain and swelling in the affected area. It&#8217;s most commonly found in the bones of the arms, legs, and pelvis.<\/p><p><span style=\"font-weight: bold;\">&#8220;Mutation&#8221;:<\/span>\u202f A &#8220;mutation&#8221; is a change or alteration in the DNA of a cell. DNA is like a set of instructions that tells cells how to function and grow. In simpler terms, a mutation is like a typo or mistake in these instructions.<\/p><p><span style=\"font-weight: bold;\">&#8220;Experimental treatment&#8221;:<\/span>\u202f &#8220;Experimental treatment&#8221; refers to a new medical approach or therapy that is still being tested and studied in a specific disease setting to understand how well it works and how safe it is. It is a treatment that doctors and researchers are trying out to see if it can help patients, but it hasn&#8217;t yet been fully approved for regular use.<\/p><p><span style=\"font-weight: bold;\">&#8220;Curative surgery&#8221;: <\/span>\u202fAn operation that aims to completely remove or fix a problem in the body, with the goal of curing the patient.<\/p><p><span style=\"font-weight: bold;\">&#8220;Oral tablets&#8221;:<\/span>\u202f Medicines that are taken by mouth and swallowed.<\/p><p><span style=\"font-weight: bold;\">&#8220;Imaging scans&#8221;:<\/span>\u202f These are special kinds of photographs that doctors use to see what&#8217;s happening inside your body without having to do surgery. Common types of imaging scans include X-rays, CT scans, MRI scans, and ultrasounds. These pictures help doctors diagnose and monitor medical conditions by showing them detailed images of bones, organs, and tissues.<\/p><p><span style=\"font-weight: bold;\">Explanation of the mode of action of the IMP: <\/span>\u202fThe experimental treatment works by blocking the activity of the altered IDH1 enzymes. By doing so, it is expected to reduce the substance called D-2-hydroxyglutarate (2-HG). This is the substance which prevents cells from developing properly. By reducing the amount of 2-HG levels, it is expected to restore the normal activity in the cells.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-26613\" class=\"elementor-tab-title\" data-tab=\"13\" role=\"button\" aria-controls=\"elementor-tab-content-26613\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Where is the study taking place?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-26613\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"13\" role=\"region\" aria-labelledby=\"elementor-tab-title-26613\"><p>If you are diagnosed with conventional chondrosarcoma and interested in taking part in the CHONQUER study and want to know if a clinical site is near you, visit our site finder.<br \/><a class=\"faqbtn\" role=\"button\" href=\"\/en-us\/am-i-eligible\/#sitefinder\">Site finder<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-26614\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-26614\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What if I have other questions?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-26614\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-26614\"><p>If you have additional questions about taking part in this study, you can share this website with your doctor to discuss the CHONQUER study.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<script type=\"application\/ld+json\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What are clinical trials?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials\\u202flook at new ways to prevent, detect, or treat disease. Clinical trials can study: new drugs or new combinations of drugs. They are tightly regulated with specific criteria for gathering data and most importantly, protect the patient participating in the clinical trial.<\\\/p><p>Your care and treatment are carefully monitored and controlled. The medical team conducting the trial will inform you about every possible outcome and they\\u2019ll explain everything that is occurring. Finally, you are free to stop the trial at any time. You can request information about clinical trials, and presuming you meet the trial criteria, you can participate in a clinical trial at any point in your cancer journey.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"How does the research process work?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>A clinical trial is led by a principal investigator (PI). Members of the research team regularly monitor the participants\\u2019 health through testing to determine the study\\u2019s safety and effectiveness. Participating in a clinical trial may take more time than standard treatment, and you may have more tests and treatments than you would if you were not participating in a clinical trial. The study team also may ask you to keep a log of symptoms or other health measures, fill out forms about how you feel, or complete other tasks. You may also need to travel to take part in a study.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is IDH1 mutation and what does it mean to me?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>The IDH1 gene mutation refers to a specific alteration in the isocitrate dehydrogenase 1 (IDH1) that affects how cells produce energy and function. This mutation can lead to the buildup of a substance called D-2-hydroxyglutarate (2-HG), which interferes with normal cell function, including DNA repair and gene regulation. This disruption can contribute to cancer development and progression. Approximately 50% of conventional chondrosarcomas have an IDH1 mutation.<\\\/p><p>For people with chondrosarcoma, having an IDH1 mutation may make them eligible for the CHONQUER study. This clinical trial is assessing an investigational treatment targeting the IDH1 mutation, offering a potential option for managing this condition.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between a clinical study and my regular medical care?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>The purpose of regular medical care is to improve or otherwise manage your health. A clinical study does not replace your regular medical care. Its purpose is to gather information to advance science and discover new treatments.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"Who is eligible for a clinical study?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Each clinical trial defines who is eligible to take part in the study. The protocol outlines the factors which include or exclude a potential participant. The study must include only people who match the required characteristics of participants for that study.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is a Placebo?\\u00a0\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Clinical trials compare a new medication, new product, or new procedure with another that already exists. In these types of studies, you may be assigned to receive a <span style=\\\"font-weight: 500;\\\">placebo<\\\/span>. A placebo is a \\u201csugar pill\\u201d that resembles medication, or a product being tested but has no treatment value. Clinical trial participants may receive a placebo to compare results on the risks and benefits of a medication and learn from their differences.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is Randomization?\\u00a0\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Randomization in clinical trials means that each participant has an equal chance of being in any of the groups of the trial (for example, a group receiving the study medicine or a group receiving the placebo). It is an important method to reduce the risk of bias in the outcomes of the trial.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is a Blinded study (single-blind\\\/double-blind)?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Blinded studies are designed to prevent members of the research team and clinical trial participants from influencing the results by not knowing if the patient is receiving placebo or treatment.<\\\/p><p>In\\u202fa <span style=\\\"font-weight: 500;\\\">single-blind <\\\/span>study, you are not told what is being given, but the research team knows.<\\\/p><p>In a <span style=\\\"font-weight: 500;\\\">double-blind<\\\/span> study, neither you nor the research team are told what you are given. Members of the research team are not told which participants are receiving which treatment to reduce bias. If it becomes medically necessary, however, it is always possible to find out which treatment you are receiving.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"Unblinding and Cross-over\\u00a0\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>In a blind study, all participants are monitored to determine if the medication or product being studied is safe and effective. If participants in this particular clinical trial who are being monitored show that the chondrosarcoma is getting worse on the radiographic images, the researchers will unblind the study to determine if you received the medication or a placebo. If you received a placebo, you would have the option to take the medication being studied and continue with the trial. If you were on the medication itself, the investigator will determine if you could still benefit by continuing the study treatment or not.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What is informed consent?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>Informed consent is the process of providing you with all the key information about a research study before you decide whether to accept the offer to participate.<\\\/p><p><span style=\\\"font-weight: 500;\\\">It is very important that you fully understand the terms, conditions, risks and benefits.<\\\/span><\\\/p><p>Taking part in a clinical trial is voluntary and you can leave the study at any time. To participate, it will be necessary for you to sign an informed consent document. To help you decide whether to take part in the clinical trial, the staff of the research team are responsible for explaining all the details of the study and making sure you understand the research process as well as the terms and conditions of the study.<\\\/p><p>The research team provides an informed consent document that includes details about the study, such as its purpose, how long it\\u2019s expected to last, tests or procedures that will be done as part of the research, and who to contact for further information. The informed consent document also explains the risks and potential benefits. Once you understand all the conditions included in the document, you can then decide whether to participate and sign the document.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"How long do I need to take part in this clinical study?\\u00a0\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>The length of a clinical study can vary, but the CHONQUER study lasts until your disease really worsens or in case too many side effects are encountered. Prior to being included in this study, there is a period where your doctor will assess if all conditions needed to be included are met. If you join, you will take the study medication (or placebo) daily and attend regular check-ups to monitor your health. After treatment, follow-up visits will check your progress. Taking part in a clinical study is entirely voluntary (your choice), and you can leave at any time without explanation or any negative impact on your regular healthcare. Additionally, the study team may stop your participation if needed for health or safety reasons.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"Glossary for the Video\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p><span style=\\\"font-weight: bold;\\\">\\u201cConventional&#8221;: <\\\/span>\\u202f&#8221;Conventional&#8221; in general means something that is traditional, standard, or commonly used and accepted. In the video it is mentioned in the context of \\u201cconventional chondrosarcoma&#8221;.\\u00a0 Conventional chondrosarcoma is a type of cancer that starts in the cartilage, which is the tough, flexible tissue that helps cushion joints and supports various structures in the body. It is a cancer that forms in the cartilage cells. This type of cancer typically grows slowly and can cause pain and swelling in the affected area. It&#8217;s most commonly found in the bones of the arms, legs, and pelvis.<\\\/p><p><span style=\\\"font-weight: bold;\\\">&#8220;Mutation&#8221;:<\\\/span>\\u202f A &#8220;mutation&#8221; is a change or alteration in the DNA of a cell. DNA is like a set of instructions that tells cells how to function and grow. In simpler terms, a mutation is like a typo or mistake in these instructions.<\\\/p><p><span style=\\\"font-weight: bold;\\\">&#8220;Experimental treatment&#8221;:<\\\/span>\\u202f &#8220;Experimental treatment&#8221; refers to a new medical approach or therapy that is still being tested and studied in a specific disease setting to understand how well it works and how safe it is. It is a treatment that doctors and researchers are trying out to see if it can help patients, but it hasn&#8217;t yet been fully approved for regular use.<\\\/p><p><span style=\\\"font-weight: bold;\\\">&#8220;Curative surgery&#8221;: <\\\/span>\\u202fAn operation that aims to completely remove or fix a problem in the body, with the goal of curing the patient.<\\\/p><p><span style=\\\"font-weight: bold;\\\">&#8220;Oral tablets&#8221;:<\\\/span>\\u202f Medicines that are taken by mouth and swallowed.<\\\/p><p><span style=\\\"font-weight: bold;\\\">&#8220;Imaging scans&#8221;:<\\\/span>\\u202f These are special kinds of photographs that doctors use to see what&#8217;s happening inside your body without having to do surgery. Common types of imaging scans include X-rays, CT scans, MRI scans, and ultrasounds. These pictures help doctors diagnose and monitor medical conditions by showing them detailed images of bones, organs, and tissues.<\\\/p><p><span style=\\\"font-weight: bold;\\\">Explanation of the mode of action of the IMP: <\\\/span>\\u202fThe experimental treatment works by blocking the activity of the altered IDH1 enzymes. By doing so, it is expected to reduce the substance called D-2-hydroxyglutarate (2-HG). This is the substance which prevents cells from developing properly. By reducing the amount of 2-HG levels, it is expected to restore the normal activity in the cells.<\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"Where is the study taking place?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>If you are diagnosed with conventional chondrosarcoma and interested in taking part in the CHONQUER study and want to know if a clinical site is near you, visit our site finder.<br \\\/><a class=\\\"faqbtn\\\" role=\\\"button\\\" href=\\\"\\\/en-us\\\/am-i-eligible\\\/#sitefinder\\\">Site finder<\\\/a><\\\/p>\"}},{\"@type\":\"Question\",\"name\":\"What if I have other questions?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"<p>If you have additional questions about taking part in this study, you can share this website with your doctor to discuss the CHONQUER study.<\\\/p>\"}}]}<\/script>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3224687 e-flex 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!important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f7c71f elementor-list-item-link-inline elementor-icon-list--layout-traditional elementor-widget elementor-widget-icon-list\" data-id=\"3f7c71f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-3f7c71f{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d540a51 elementor-list-item-link-inline elementor-icon-list--layout-traditional elementor-widget elementor-widget-icon-list\" data-id=\"d540a51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.nimh.nih.gov\/health\/trials\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">NIMH's clinical trials webpage <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medlineplus.gov\/\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 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href=\"https:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Clinical Trials webpage <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">PubMed\u00ae database <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.nih.gov\/health-information\/nih-clinical-research-trials-you\/basics\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">The Basics | National Institutes of Health (NIH)<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b3dbfa elementor-list-item-link-inline elementor-icon-list--layout-traditional elementor-widget elementor-widget-icon-list\" data-id=\"6b3dbfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-6b3dbfa{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>FAQs Here, you will find answers to other questions you may have about this study. What are clinical trials? Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials\u202flook at new ways to prevent, detect, or treat disease. Clinical trials can study: new drugs or new combinations of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":0,"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"wp:attachment":[{"href":"https:\/\/chonquer.com\/en-ca\/wp-json\/wp\/v2\/media?parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}