The CHONQUER study

Welcome!

This website provides information about a current study for patients with locally advanced and metastatic conventional chondrosarcoma.

Why are we doing this study?

The CHONQUER study is a clinical research study exploring a new treatment for adults with locally
advancedⓘThe illness has spread beyond its original location but has not reached distant parts of the body. or metastaticⓘThe illness has spread from its original location to other parts of the body. conventional chondrosarcomaⓘA type of cancer that starts in the cartilage, which is the tough, flexible tissue that helps cushion joints and supports various structures in the body. In simpler terms, it is a cancer that forms in the cartilage cells. This type of cancer typically grows slowly and can cause pain and swelling in the affected area. It is most commonly found in the bones of the arms, legs and pelvis.
Chondrosarcoma is a rare cancer that usually starts in the bones. It is the most common form of bone sarcoma in adults. While surgery is currently the most common treatment option, many patients experience a return of their disease after surgery, and these tumours tend to resist chemotherapy.

Chondrosarcoma is a serious condition and has no approved medications. New treatment options are urgently needed. In this study, researchers aim to find out if the study drug, an investigational treatment (a drug being studied in a research setting, which has not yet been approved for use in this disease setting), may be safe and effective in managing this rare bone sarcoma.

By participating, you will help researchers learn more about this rare bone cancer and provide hope for better care for others living with chondrosarcoma in the future.

To learn more about the treatments being studied in the CHONQUER study, visit our About CHONQUER page.

The results of a prior study in early phase are described under the below link. It provides an explanation why we are now doing CHONQUER.

Clinical trial summary

Who can take part in this study?

We are looking for participants who:

Are 18 years or older
Have been diagnosed with locally advancedⓘThe illness has spread beyond its original location but has not reached distant parts of the body. or metastaticⓘThe illness has spread from its original location to other parts of the body. conventional chondrosarcomaⓘA type of cancer that starts in the cartilage, which is the tough, flexible tissue that helps cushion joints and supports various structures in the body. In simpler terms, it is a cancer that forms in the cartilage cells. This type of cancer typically grows slowly and can cause pain and swelling in the affected area. It is most commonly found in the bones of the arms, legs and pelvis. .
Have a specific genetic mutation (IDH1), which will be confirmed by testing in the framework of the study

Please note: There are additional requirements to participate. If you are interested in taking part in this study, you can share this website with your primary care doctor, General Practitioner, oncologist or contact the designated Principal Investigator for the study identified e.g. via the site finder. 

What Else Should I Know?

Participation in a clinical study is voluntary and making the decision to enrol is key but can be very challenging.

Without clinical trials, many of the medical treatments and cures would not exist. Clinical trials help bring new drugs to the market. The goal of a clinical trial is to determine if interventions are safe and effective. Clinical trials look at new ways to prevent, detect or treat the disease. 

There is no guarantee of medical benefit. Your condition may improve, stay the same or worsen. The study drug may cause side effects, but your health will be closely monitored throughout the study. You can leave the study at any time without it affecting your usual healthcare.

If you are diagnosed with conventional chondrosarcoma and you think you might be interested in taking part, or would like more information, you can share this website with your primary care doctor, General Practitioner, oncologist or contact the designated Principal Investigator for the study – they are happy to answer any questions that you have.   

Find a clinical site near you.

If you have any questions about clinical studies in general or this study, we also encourage you to discuss the CHONQUER study with your primary care doctor, General Practitioner or oncologist.  